Speed Up & Sit StillSpeed Up & Sit Still » John Mendoza http://speedupsitstill.com The Story of ADHD in Australia Fri, 21 Mar 2014 02:19:54 +0000 en-US hourly 1 http://wordpress.org/?v=3.6.1 Extra EPPIC and Headspace funding in the Federal Budget: A quick fix to a political problem but where is the evidence?http://speedupsitstill.com/extra-eppic-headspace-funding-federal-budget-quick-fix-political-problem-evidence http://speedupsitstill.com/extra-eppic-headspace-funding-federal-budget-quick-fix-political-problem-evidence#comments Sat, 28 May 2011 16:18:50 +0000 martin http://speedupsitstill.com/?p=1597 The following is an edited excerpt from a speech Martin Whitely MLA made in the Western Australian Legislative Assembly on Wednesday 25 May 2011

Mental Health was a centrepiece of the federal budget, with an additional $2.2 billion being identified over five years for mental health initiatives, of which $419.7 million was split between the Early Psychosis Prevention and Intervention Centre (EPPIC), and Headspace.[1] An additional $2.2 billion for mental health is a good thing and to the extent that people such as Professor Patrick McGorry, Professor Ian Hickie and Professor John Mendoza, have contributed to putting mental health on the agenda, they deserve praise. However, I am concerned that the devil is in the detail. My criticism is not about extra funding but about the lack of an evidence base for the decisions that have been made.

Politics not science drove the Gillard Government’s mental health response.

I suggest that this response was a political response to a political problem, not a public policy response based on thorough analysis of the evidence. I criticise not only the Gillard government but also the Abbott opposition, the independents and, indeed, the media. They have all allowed the mental health debate to be dominated by a tiny group—Patrick McGorry, Ian Hickie and John Mendoza.

I am not suggesting that those people do not have valuable contributions to make. However, I am saying that they are not the independent mental health spokespersons that they are portrayed to be in the media; they are players with vested interests.[2] That has been missed by the media, the opposition, the federal government and even the independents in federal Parliament. Those three gentlemen are fantastic advocates and great political lobbyists, but I am not convinced that they have been asked enough tough questions about the programs they advocate for and control—particularly EPPIC and Headspace. I am concerned about the potential for off-label prescribing in expanded EPPIC and Headspace services, and the potential for this to do enormous harm to young people in Australia.

Before I talk about that, I will talk about the political process involved and highlight how unusual it was. The Minister for Mental Health and Ageing has the National Advisory Council on Mental Health to give him advice on strategic directions for mental health. The Minister for Mental Health and Ageing took the extraordinary step of sidelining the National Advisory Council and set up the Mental Health Expert Working Group.[3] Three members of that group—Professor McGorry, Professor Ian Hickie and Monsignor David Cappo—left that group and produced their own $3.5 billion five-year blueprint for mental health under the banner of the Independent Mental Health Reform Group.[4] It is interesting that both Professors McGorry and Hickie have extensive and longstanding commercial ties to the pharmaceutical industry, so I have some questions about the use of the term “independent”.

Extra EPPIC and Headspace funding may see increased ‘off label’ prescribing of SSRI Antidepressants to young people and more youth suicides.

The blueprint they came up with identified $226 million for Headspace, which ended up getting $197.3 million and $910 million for Early Psychosis Prevention and Intervention Centres, which received $222.4 million. The EPPIC funding is supposed to be matched by state governments. I suggest that state governments need to have a good think about whether they do that.

I am very concerned that we will see through Headspace and EPPIC an increase in the off-label prescription of selective serotonin reuptake inhibitor (SSRI) antidepressants, despite the clinical trial evidence that is accepted by the Therapeutic Goods Administration and the US Food and Drug Administration that using SSRI antidepressants leads to a significant increase in the prospects of young people under the age of 24 years being suicidal—an increase of 80 per cent. Regardless both Headspace and EPPIC advocate the use of SSRI antidepressants for all young people with moderate to severe depression.[5]

This document titled, “Using SSRI Antidepressants to Treat Depression in Young People: What are the Issues and What is the Evidence?”[6] was produced by Headspace in 2009 and has five authors, including Patrick McGorry. It concludes by stating —In cases of moderate to severe depression, SSRI medication may be considered within the context of comprehensive management of the patient, which includes regular careful monitoring for the emergence of suicidal ideation or behaviour.

Yet the body of the paper builds a compelling case for not using SSRI antidepressants. It acknowledges that the only SSRI that has positive outcomes in clinical trials is fluoxetine and that even those benefits seem to disappear the longer one looks at the evidence. The paper also highlights the fact that clinical trials indicate that compared to taking a placebo, SSRI antidepressants increase the probability of a young person being suicidal by 80 per cent.

One has to bear this in mind against the political process that was used to sell the need for expansions of Headspace services. It was done against the background of candlelight vigils that were coordinated through Get Up! to highlight concerns about youth suicide and create momentum for increased funding to youth-oriented mental health services. However, the very services that the federal government is funding prescribe against TGA and FDA recommendations and against the (suicidal behaviour) black box warnings that exist for SSRI antidepressants.

Therefore I am very concerned that if this issue of SSRI antidepressant ‘off label’ prescribing is not addressed at both Headspace and EPPIC, we may see an increase in the number of candles at the next vigil.

Patrick McGorry on EPPIC - Contradictory and Confusing

My concerns about EPPIC are less straightforward. EPPIC is very much Professor McGorry’s baby and is based on the principle that early intervention can prevent later psychosis—the philosophy that a stitch in time saves nine. I support the philosophy of early intervention. Members who have listened to my speeches in the past will be bleeding from the ears hearing me plead for the need for early intervention so that we can identify kids’ real health, education and social needs. My concern is not that we do not need early intervention but what that early intervention will be.

At my invitation, Professor McGorry replied to my latest blog. We also had an exchange on The World Today program on ABC radio on 12 May in which I outlined my concerns, and on 20 May Professor McGorry responded. As I said, we are halfway through what I believe is going to be a constructive and cordial exchange. (we are meeting in late June)

However, I want to put on record my prime issue so there is absolutely no ambiguity about it. What we need from Professor McGorry, on behalf of EPPIC, is a very clear unambiguous statement about the circumstances under which antipsychotics will be prescribed at EPPIC, and we need a very clear statement about the future of Psychosis Risk Syndrome. I will not beat around the bush. To date, what Professor McGorry has said and written is confusing for those who follow it closely. It is confusing for one very clear reason: he has contradicted himself too often.

Specifically, I want to begin with the issue of psychosis risk syndrome, otherwise known as attenuated psychotic syndrome. Dr Allen Frances, the psychiatrist who led the redevelopment of DSM­IV, the bible of psychiatry, had some very unflattering things to say about psychosis risk syndrome. He said —“Psychosis Risk Syndrome” stands out as the most ill-conceived and potentially harmful …(Of all the proposals for insertion into DSM­5) — The whole concept of early intervention rests on three fundamental [flawed] pillars … 1) it would misidentify many teenagers who are not really at risk for psychosis; 2) the treatment they would most often receive (atypical antipsychotic medication) has no proven efficacy; but, 3) it does have definite dangerous complications.” [7] They are the words of the man who led the redevelopment of DSM­IV. These are not the words of someone at the fringe of psychiatry. These are words from the very heart of psychiatry.

When I was on The World Today on 12 May I said that Professor McGorry is a leading international proponent of Psychosis Risk Syndrome a new psychiatric disorder for inclusion in the next edition of DSM­5. On the long version of the audio version on The World Today website, Professor McGorry said — Contrary to Mr Whitely’s statements, I haven’t been pushing for it —(That is, psychosis risk syndrome) — to be included in DSM­5. Now that hasn’t been my position…But it’s a new area of work. It’s only been studied for the last 15 years or so, so you know we haven’t got all the answers … I’m certainly not saying that it should go into DSM­5.[8]

So on two occasions in that interview he said that he was not advocating it should go into DSM­5. That is just plain wrong. I have an article that was published in Psychiatry update a year ago entitled “DSM­V ‘risk syndrome’: a good start, should go further”. [9] It begins by stating — The proposal for DSM­V to include a ‘risk syndrome’ reflecting an increased likelihood of mental illness is welcome but does not go far enough, according to Orygen Youth Health’s director Professor Patrick McGorry.

That is somebody else paraphrasing his words, so I went to the original source document, which is an article available in the Science Digest under “Schizophrenia Research”.[10] It is written by Professor McGorry and the opening sentence states — The proposal to consider including the concept of the risk syndrome in the forthcoming revision of the DSM classification is innovative and timely. It has not come out of left field, however, and is based upon a series of conceptual and empirical foundations built over the past 15 years.

That is absolutely clear-cut. I could build a case in greater detail but Professor McGorry has clearly advocated the inclusion of psychosis risk syndrome, otherwise known as attenuated psychosis syndrome in DSM­5. (Note; Far from rejecting the notion of Psychosis Risk Syndrome McGorry argues for the recognition of yet another disorder, General Distress Syndrome, for those with even less acute, ill-defined symptoms ).[11]

In the same interview, Professor McGorry said — Medication should never be the first line of treatment in young people, we should always try to find psychological and simpler ways of treating youth mental health issues, that is where I agree with him (Martin Whitely) but where I part company is where he tried to I suppose confuse the issue by, I suppose, denying any value to these medications. They clearly do have value, the anti-psychotic medications, in people with clear­cut psychosis.

I have never been critical of the on-label prescription of antipsychotics to people who have had a psychotic break. Professor McGorry is quite wrong in characterising me as saying that. But that is not of any great consequence because, after all, it just relates to me being misrepresented.

Another misrepresentation is of greater consequence because he contadicted EPPIC’s position when he said that — Medication should never be the first line of treatment in young people, we should always try to find psychological and simpler ways of treating people with youth mental health issues. EPPIC guidelines (at least in regard to the use of antidepressants in young people) clearly identified that all those presenting with a depressive episode of at least moderate severity should be commenced on an antidepressant.[12] It does not even narrow it down to Fluoxetine, the one selective serotonin reuptake inhibitor identified as having some positive effects. It just says “antidepressant”.

That is not the only misrepresentation. Professor McGorry also claimed, in response to my blog[13], that EPPIC followed the beyondblue guidelines with regard to the use of SSRI’s. That is not true. The beyondblue guidelines are far more cautious in its recommendations about the use of SSRIs or antidepressants.[14] Professor McGorry is simply wrong to say that EPPIC follows the Beyondblue guidelines for the use of antidepressants.

I have a number of other concerns. (Especially the EPPIC guideline that states ‘All individuals with an ‘at risk’ mental state, e.g. siblings of  EPPIC clients, will be referred to PACE clinic for assessment. [15]) Unfortunately, I will run out of time but a major concern is with the use of antipsychotics in non-­psychotic teenagers by EPPIC. EPPIC’s target audience is young people between the ages of 15 to 24 years. Professor McGorry and EPPIC have to answer the following very simple question: under what circumstances, if any, will EPPIC either recommend or prescribe antipsychotics to patients who have not experienced psychosis?

EPPIC and Professor McGorry need to make their position clear because at the moment it is not clear. I mistakenly thought it was made clear in a previous blog that I had written when a spokesperson for Professor McGorry, Matthew Hamilton, made some quite promising statements that indicated that they were no longer proposing the use of antipsychotics for psychosis risk syndrome.[16] Since then, we have seen some ambiguous and contradictory statements by Professor McGorry that have left that door open.[17] We need to have a very clear answer from Professor McGorry on behalf of EPPIC as to when, if ever, antipsychotics will be used by those who have never been psychotic.

Clarrity at least is required, but in my opinion EPPIC and Headspace need to abandon prescribing antidepressants altogether to under 18′s and rule out the use of antipsychotics in non-psychotic young people. If they stick to ‘on label’ prescribing, we can be confident that the extra $419.7 M for EPPIC and Headspace will do more good than harm. This requires a change from experimental, hypothesis based, psychiatry to an evidence based, ’first do no harm’ mindset.

Update – Some progress has been made on the issues identified above see http://speedupsitstill.com/australian-16-june-2011

Coming Blogs – Mental health screening for three year olds and the budget cuts to psychology services: Are these a recipe for more dumbed down, psychiatric labelling and prescribing?

I ran out of time in the speech to outline all of my concerns with the mental health response in the 20011/12 federal budget. I am alarmed at the proposals for mental health screening of three year olds and despair at the cuts to support for psychological services, in order to fund GP mental health visits. Both of these measures have the potential to further promote the increasingly dominant dumbed down, ‘label and prescribe’ approach to mental health, however these are topics for another speech and blog.

Related Media

Minds at Risk: Choosing the Right Path for Adolescent Mental Health, Lisa Pryor, The Monthly July 2011 http://www.themonthly.com.au/choosing-right-path-adolescent-mental-health-minds-risk-lisa-pryor-3470


[1] Prime Minister and Minister for Mental Health Joint Press Release, 13 May 2011, 2011-12 Budget Offers Greater Support for Mental Health Patients 2011-12 Budget Offers Greater Support for Mental Health Patients (accessed 28 May 2011)

[2] Professor McGorry was the former President and is the current Treasurer (http://www.iepa.org.au/ContentPage.aspx?pageID=40) of the “International Early Psychosis Association” which is funded by antipsychotic manufacturers Astra Zeneca, Lilly and Janssen-Cilag (http://www.iepa.org.au/2010/) McGorry is currently Director of Clinical Services at Orygen Youth Health Clinical Program and Executive Director of the Orygen Youth Health Research Centre. Orygen Youth Health receives support from AstraZeneca, Bristol Myer Squibb, Eli Lilly, and Janssen-Cilag. Orygen Youth Health, Research Centre – Other Funding http://rc.oyh.org.au/ResearchCentreStructure/otherfunding (accessed 3 August 2010) McGorry individually has received unrestricted grants from Janssen-Cilag, Eli Lilly, Bristol Myer Squibb, Astra-Zeneca, Pfizer, and Novartis and has acted as a paid consultant or speaker for most of these companies McGorry P.D. ‘Is early intervention in the major psychiatric disorders justified? Yes’, BMJ 2008;337:a695 http://www.bmj.com/cgi/content/full/337/aug04_1/a695 (accessed 3 August 2010)

Professor Hickie and colleagues created the ‘SPHERE: A National Depression Project’ (http://sydney.edu.au/bmri/about/Hickie_CV.pdf). As was reported in The Australian Pfizer work in conjunction with SPHERE through a company called Lifeblood who are paid to review SPHERE. Through the use of SPHERE Pfizer have restored Zoloft to the number one antidepressant in Australia. (http://www.theaustralian.com.au/news/health-science/gp-jaunts-boosted-drug-sales/story-e6frg8y6-1225890003658). Professor Hickey received the following grants totalling $411,00 from pharmaceutical companies: $10,000 from Roche Pharmaceuticals (1992); $30,000 from Bristol-Myers Squibb (1997); $40,000 from Bristol-Myers Squibb (1998-1999); $250,000 from Pfizer Australia (2009); $81,000 from Pfizer Australia (n.d.) Cited in Ian Hickie, Curriculum Vitae, last updated 23 August 2009 http://sydney.edu.au/bmri/about/Hickie_CV.pdf   (accessed 3 August 2010)

Professor Mendoza was co-author of the “Not for Service” report which was issued in 2005.  Apart from the Commonwealth Govt, the report was funded by unrestricted grants from AstraZeneca, Bristol-Myers Squibb, Eli Lilly Australia, GlaxoSmithKline, Medicines Australia, Pfizer Australia and Wyeth. (Not For Service: Experiences of Injustice and Despair in Mental Health Care in Australia, Mental Health Council of Australia, Canberra, 2005 http://www.hreoc.gov.au/disability_rights/notforservice/documents/NFS_Finaldoc.pdf (3 August 2010)). He is also a principle of ConNetica Consulting Pty Ltd, whilst they have very broad purposes such as providing a review, survey and planning service to government and not for profit organizations, including those involved in mental health. It currently lists Eli Lilly as one of its private sector clients (ConNetica Consulting, About Us http://connetica.com.au/about_us (accessed 3 August 2010))

[3] Advisory Group to Guide Mental Health Reforms (23 December 2010), Pro Bono News Advisory Group to Guide Mental Health Reforms (accessed 26 April 2011)

[4] Including, Connecting, Contributing: A Blueprint to Transform Mental Health and Social Participation in Australia, March 2011. Prepared by the Independent Mental Health Reform Group: Monsignor David Cappo, Professor Patrick McGorry, Professor Ian Hickie, Sebastian Rosenberg, John Moran, Matthew Hamilton A Blueprint to Transform Mental Health and Social Participation in Australia (accessed 26 April 2011)

[5] Hammad T.A. (16 August 2004). Review and evaluation of clinical data. Relationship between psychiatric drugs and pediatric suicidal behavior, Food and Drug Administration. pp. 42; 115. FDA Review and evaluation of clinical data (accessed 29 May 2008)

[6] Evidence Summary: Using SSRI Antidepressants to Treat Depression in Young People: What are the Issues and What is the Evidence? Headspace, Evidence Summary Writers Dr Sarah Hetrick, Dr Rosemary Purcell, Clinical Consultants Prof Patrick McGorry, Prof Alison Yung, Dr Andrew Chanen  Headspace Evidence Summary (accessed 28 May 2011)

[7] Frances, A. (2010) DSM5 ‘Psychosis risk syndrome’—Far too risky, Psychology Today Psychosis risk syndrome—Far too risky

[8] The World Today – Professor McGorry hits back at critics, 20 May 2011 www.abc.net.au/worldtoday/content/2011/s3222359.htm (accessed 28 May 2011)

[9] Available at http://www.psychiatryupdate.com.au/news/DSM-V-risk-syndrome-a-good-start-should-go-further accessed 28 May 2011

[10] McGorry, P.D. Risk Syndromes, clinical staging and DSM V; New diagnostic infrastructure for early intervention in psychiatry, Schizophr, Res. (2010), doi;10.1016/j.schres.2010.03.016

[11] See  http://speedupsitstill.com/patrick-mcgorry-early-intervention-psychosis-stitch-time-stitch-up

[12] EPPIC guidelines state that all clients experiencing ‘a depressive episode of at least moderate severity should be commenced on an antidepressant.’ http://www.eppic.org.au/eppic-clinical-guidelines (accessed 28 May 2011)

[13] http://speedupsitstill.com/patrick-mcgorry%e2%80%99s-independent-mental-health-reform-group%e2%80%99s-3-5b-blueprint-australian-mental-health-forward-prescription-%e2%80%98psychiatric-disorders%e2%80%99-%e2%80%98off-label#more-1530

[14] In comparison to the EPPIC Guidelines which say that all clients experiencing ‘a depressive episode of at least moderate severity should be commenced on an antidepressant.’ the beyondblue clinical practice guidelines (page 55) state: ‘If symptoms are severe, or if symptoms are moderate to severe and psychological therapy has not been effective, is not available or is refused, prescription of the selective serotonin reuptake inhibitor (SSRI) antidepressant fluoxetine should be considered for reducing depression symptoms in the short term.’ http://beyondblue.org.au/index.aspx?link_id=6.1247 accessed 28 May 2011

[15] http://www.eppic.org.au/eppic-clinical-guidelines (accessed 28 May 2011)

[16] See http://speedupsitstill.com/patrick-mcgorry-reverses-support-psychosis-risk-syndrome-drugging

[17] In December 2010 Professor McGorry wrote Antipsychotic medications should not be considered unless there is a clear-cut and sustained progression to frank psychotic disorder meeting full DSM 4 criteria.’ He then immediately invalidated this statement by writing, ‘The only exception to the previous statement is where there has been a definite failure to respond to the first and second line interventions described above AND there is worsening and continuing disability, or significant risk of self-harm, suicide or harm to others arising directly from the mental disorder itself and its symptoms. In this situation, a trial of low dose antipsychotic medication for 6 weeks in the first instance may be appropriate, with careful monitoring for adverse events.’ The term mental disorder itself is interesting as he is referring Psychosis Risk Syndrome which is not officially recognised as a legitimate psychiatric disorder and hopefully never will be. See http://speedupsitstill.com/reply-patrick-mcgorry-early-intervention-psychosis#more-1075

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Australian of the Year Patrick McGorry’s call for early intervention to prevent Psychosis: A Stitch in Time or a Step too Far?http://speedupsitstill.com/patrick-mcgorry-early-intervention-psychosis-stitch-time-stitch-up http://speedupsitstill.com/patrick-mcgorry-early-intervention-psychosis-stitch-time-stitch-up#comments Sun, 21 Nov 2010 03:56:14 +0000 martin http://speedupsitstill.com/?p=753 No sensible person would argue against Australian of the Year, psychiatrist Patrick McGorry’s call for early intervention to prevent psychosis; unless of course you know the detail of what Professor McGorry has advocated as early intervention. Put bluntly, Professor McGorry has advocated the use of antipsychotics, with a host of serious potential adverse side effects, on the hunch that adolescents may later become psychotic.

Specifically Professor McGorry is a leading international advocate for the inclusion of Psychosis Risk Syndrome, otherwise known as Attenuated Psychotic Symptoms Syndrome, in the next edition of the clinically dominant Statistical Manual of Mental Disorders (DSM-V) due for publication in 2013. He acknowledges that ‘the false positive rate may exceed 50-60%’ nonetheless has justified the use of pre-psychosis drugs by arguing ‘all those identified are by definition seeking help and need some form of care’.[1]

Criticism of his views on the use of pre-psychosis drugs have received limited publicity within Australia. However, in 2006 Time Magazine (Drugs before Diagnosis) stated ‘Calm and softly spoken, McGorry has a way of making the experimental use of antipsychotics seem like the only responsible course.’ Time outlined how Professor McGorry trialled the antipsychotic, Risperidone, on subjects without psychosis but that were suspected of being at risk of developing psychotic disorders such as schizophrenia.[2]

Risperidone (also known as Risperdal) is one of the more commonly used antipsychotics and has a range of serious potential side effects including metabolic syndrome, and sudden cardiovascular death.[3] [4] There have been more than 500 voluntary adverse event reports made to the TGA and these are just the tip of the iceberg as the vast majority of adverse events are never reported. [5] [6]

The results of Professor McGorry’s Risperidone trial were inconclusive; however Time describes McGorry’s determination to push on ‘full steam ahead – and damn the torpedoes.’[7] And Professor McGorry did push ahead, but now many of his international colleagues in the psychiatric profession are pushing back.

Dr Allen Frances the American Psychiatrist who led the 1994 revision of the current edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) is a fierce critic of Psychosis Risk Syndrome. With the benefit of hindsight he regrets aspects of the 1994 revision for having triggered ‘three false epidemics. One for autistic disorder… another for the childhood diagnosis of Bi-Polar disorder and the third for the wild over-diagnosis of Attention Deficit Disorder.’[8] Based on this experience Dr Frances warns of numerous problems with the drafting of the next edition DSM-V, recently writing that;

‘Among all the problematic suggestions for DSM-V, the proposal for a “Psychosis Risk Syndrome” stands out as the most ill-conceived and potentially harmful… The whole concept of early intervention rests on three fundamental [flawed] pillars… 1) it would misidentify many teenagers who are not really at risk for psychosis; 2) the treatment they would most often receive (atypical antipsychotic medication) has no proven efficacy; but, 3) it does have definite dangerous complications.”[9]

Dr Frances contends that up to 90% of those diagnosed with Psychosis Risk Syndrome would never go onto develop psychosis and concludes it is ‘the prescription for an iatrogenic [adverse effects resulting from treatment] public health disaster’.[10]

Critics closer to home include Adelaide University Associate Professor, and Head of the Department of Psychological Medicine at the Women’s and Children’s Hospital in Adelaide, Dr Jon Jureidini, who in the August 2010 said that Professor McGorry had falsely claimed that 750,000 young Australians were ‘locked out’ of care they ‘desperately’ needed. ‘He’s taken the biggest possible figure you can come up with for people who might have any level of distress or unhappiness, which of course needs to be taken seriously and responded to, but he’s assuming they all require … a mental health intervention…It’s the way politicians operate. You look at figures and put a spin on it that suits your point of view. I don’t think that has a place in scientific conversations about the need for health interventions.’[11]

Even one of Professor McGorry’s colleagues at the Orygen Youth Health Research Centre, Alison Yung, recently expressed strong opposition to the inclusion of Psychosis Risk Syndrome in DSM-IV stating;

‘I think the issue of antipsychotics is a crucial one. If someone meeting risk syndrome criteria also has depression and anxiety (the majority do), could they not be treated with psychological therapies such as cognitive behavioral therapy? So why the need for a specific risk syndrome diagnosis? Is the agenda really to use antipsychotics? …….I think there are concerns about validity, especially predictive validity, and this relates to potentially stigmatizing and unjustified treatment for some individuals as well as all the negative social effects of diagnosis. I think including the risk syndrome in the DSM-V is premature…….more people seek help, but the risk is that instead of getting maybe supportive therapy, they get antipsychotics and they will be diagnosed with the risk syndrome.’[12]

Perhaps due to his Australian of the year status Professor McGorry is frequently quoted by the Australian media as an independent advocate for mental health reform. However he, and organisations he is influential in, have received support from the pharmaceutical industry.  Along with being treasurer and former president of the pharmaceutical industry funded International Early Psychosis Association,  McGorry is currently Director of Clinical Services at Orygen Youth Health Clinical Program and Executive Director of the Orygen Youth Health Research Centre. Orygen Youth Health Research Centre receives support from numerous pharmaceutical companies.[13] [14] Professor McGorry individually has received unrestricted grants from Janssen-Cilag, Eli Lilly, Bristol Myer Squibb, Astra-Zeneca, Pfizer, and Novartis and has acted as a paid consultant for most of these companies.[15]

Professor McGorry and his colleagues Professor John Mendoza and Professor Ian Hickie (who also recive support from the pharmaceutical industry) dominated the long overdue debate about mental health policy in the lead up to the August Federal election.[16] [17] Anyone who watched Insight on SBS (27 July 2010) would have noticed how deferential the presenter, politicians and participants were to Patrick McGorry, and to a lesser extent John Mendoza. Their blessing was desperately being sought by Peter Dutton and Mark Butler on behalf of the Coalition and Labor respectively.

Most enamoured of Professor McGorry’s approach was Dutton who stated “Well, we’re going to roll out a national scheme based on advice by people like John Mendoza, Pat McGorry, Ian Hickey, David Crosby and others….early intervention is proven without any doubt to work.”[18] Mendoza reciprocated Dutton’s admiration describing the Coalition’s approach as “streets ahead. It’s literally comparing an old clunker to a brand new motor vehicle.” Largely due to the advocacy of Professor McGorry and his allies Mental health was unquestionably a net positive for the Coalition in the election.

Professor McGorry is now pressuring the Gillard Government to match the Coalition’s 2010 election commitment of $440m to EPPIC (Early Psychosis Prevention and Intervention Centres)  like those run by Orygen Youth Health which is headed up by McGorry.[19] These centres aim “to facilitate early identification and treatment of psychosis” and “reduce delays in initial treatment”.[20] It is undeniable that early intervention in the form of identifying and addressing real problems must be supported. But the majority of Adolescents ‘seeking care’ and diagnosed with Psychosis risk Syndrome would not only suffer their original difficulties but posibly from the unnecessary administration of potentially harmful antipsychotics. Professor McGorry has justified this compromise of the Hippocratic obligation to ‘first do no harm’ by arguing the ‘real danger of lack of care overshadows the theoretical one of premature labelling and overtreatment.’[21]

Irrespective of these concerns there is no doubt Professor McGorry is a fantastic salesman. He combines excessive pessimism about the widespread prevalence of mental illness and unmet need, with optimistic promises of ‘21st Century’ solutions (which happen to have been developed by him and his allies) if only government will urgently fund these ‘proven approaches’.[22]

Mental Health does deserve the national spotlight and we can be grateful that Patrick McGorry’s appointment as Australian of the Year put it on the agenda. But the public are entitled to and informed debate about exactly what is being advocated.

Access to appropriate early intervention in mental health is long overdue, however prescribing antipsychotics to adolescents on the outside chance that they may develop later psychosis, is a bit like killing a fly with a shotgum.


[1]McGorry also stated “Early intervention covers both early detection and the phase specific treatment of theearlier stages of illness with psychosocial and drug interventions. It should be as central in psychiatry as it is in cancer, diabetes, and cardiovascular disease.” McGorry P.D. ‘Is early intervention in the major psychiatric disorders justified? Yes’, BMJ 2008;337:a695 http://www.bmj.com/cgi/content/full/337/aug04_1/a695(accessed 3 August 2010)[2] Time Magazine also identified how McGorry ‘…wants to apply the principle of early diagnosis and treatment to “a range of mental health problems in young people: substance abuse, personality disorders, bipolar – the whole lot, really.’ Williams, D (18 June 2006) Drugs Before Diagnosis? Time Magazine http://www.time.com/time/magazine/article/0,9171,1205408,00.html (accessed 18 November 2010) [3] Consumer Medicine Information: Risperidone http://www.racgp.org.au/cmi/jccrispe.pdf (accessed 3 August 2010)

[4] Webb, D. & Raven M. ‘McGorry’s ‘early intervention’ in mental health: a prescription for disaster’ Online Opinion (6 April 2010) http://www.onlineopinion.com.au/view.asp?article=10267 (accessed 18 November 2010)

[5] Adverse events information related to Risperidone obtained from the Therapeutic Goods Administration’s Public Case Detail reports

[6] As reporting is voluntary there is now way of knowing what proportion of actual adverse events gets reported. A 2008 study by Curtin University pharmacologist Con Berbatis indentified that only a tiny fraction (for general practitioners only 2 per cent) of adverse events are reported. (Con Berbatis, ‘Primary care and Pharmacy: 4. Large contributions to national adverse reaction reporting by pharmacists in Australia’, i2P E-Magazine, Issue 72, June 2008, p. 1)

[7] Williams, D (2006) Drugs Before Diagnosis? Time Magazine http://www.time.com/time/magazine/article/0,9171,1205408,00.html

[8] Frances, A in Whitely, M (2010) Speed Up and Sit Still: The Controversies of ADHD Diagnosis and Treatment p.18 UWA Publishing, Crawley, Western Australia

[9] Frances, A (2010) DSM5 ‘Psychosis Risk Syndrome’—Far Too Risky Psychology Today http://www.psychologytoday.com/blog/dsm5-in-distress/201003/dsm5-psychosis-risk-syndrome-far-too-risky

[10] Frances, A (2010) DSM5 ‘Psychosis Risk Syndrome’—Far Too Risky Psychology Today http://www.psychologytoday.com/blog/dsm5-in-distress/201003/dsm5-psychosis-risk-syndrome-far-too-risky

[11] The Age Julia MedewAugust 9, 2010McGorry Misleading the parliament http://www.theage.com.au/national/mcgorry-misleading-the-public-20100808-11qes.html

[12] Schizophrenia Research Forum, Live Discussion: Is the Risk Syndrome for Psychosis risky Business http://www.schizophreniaforum.org/for/live/transcript.asp?liveID=68 Posted 4 October 2009

[13] McGorry was the former President and is the current Treasurer (http://www.iepa.org.au/ContentPage.aspx?pageID=40) of the “International Early Psychosis Association” which is funded by antipsychotic manufacturers Astra Zeneca, Lilly and Janssen-Cilag (http://www.iepa.org.au/2010/)

[14] McGorry is currently Director of Clinical Services at Orygen Youth Health Clinical Program and Executive Director of the Orygen Youth Health Research Centre. Orygen Youth Health receives support from AstraZeneca, Bristol Myer Squibb, Eli Lilly, and Janssen-Cilag. Orygen Youth Health, Research Centre – Other Funding http://rc.oyh.org.au/ResearchCentreStructure/otherfunding (accessed 3 August 2010)

[15] McGorry individually has received unrestricted grants from Janssen-Cilag, Eli Lilly, Bristol Myer Squibb, Astra-Zeneca, Pfizer, and Novartis and has acted as a paid consultant or speaker for most of these companies McGorry P.D. ‘Is early intervention in the major psychiatric disorders justified? Yes’, BMJ 2008;337:a695 http://www.bmj.com/cgi/content/full/337/aug04_1/a695 (accessed 3 August 2010)

[16] Professor Mendoza was co-author of the “Not for Service” report which was issued in 2005.  Apart from the Commonwealth Govt, the report was funded by unrestricted grants from AstraZeneca, Bristol-Myers Squibb, Eli Lilly Australia, GlaxoSmithKline, Medicines Australia, Pfizer Australia and Wyeth. (Not For Service: Experiences of Injustice and Despair in Mental Health Care in Australia, Mental Health Council of Australia, Canberra, 2005 http://www.hreoc.gov.au/disability_rights/notforservice/documents/NFS_Finaldoc.pdf (3 August 2010)). He is also a principle of ConNetica Consulting Pty Ltd, whilst they have very broad purposes such as providing a review, survey and planning service to government and not for profit organizations, including those involved in mental health. It currently lists Eli Lilly as one of its private sector clients (ConNetica Consulting, About Us http://connetica.com.au/about_us (accessed 3 August 2010))

[17] Professor Hickie and colleagues created the ‘SPHERE: A National Depression Project’ (http://sydney.edu.au/bmri/about/Hickie_CV.pdf). As was reported in The Australian Pfizer work in conjunction with SPHERE through a company called Lifeblood who are paid to review SPHERE. Through the use of SPHERE Pfizer have restored Zoloft to the number one antidepressant in Australia. (http://www.theaustralian.com.au/news/health-science/gp-jaunts-boosted-drug-sales/story-e6frg8y6-1225890003658). Professor Hickey received the following grants totalling $411,00 from pharmaceutical companies: $10,000 from Roche Pharmaceuticals (1992); $30,000 from Bristol-Myers Squibb (1997); $40,000 from Bristol-Myers Squibb (1998-1999); $250,000 from Pfizer Australia (2009); $81,000 from Pfizer Australia (n.d.) Cited in Ian Hickie, Curriculum Vitae, last updated 23 August 2009 http://sydney.edu.au/bmri/about/Hickie_CV.pdf (3 August 2010) Some of these research funds were for a trial for a new antipsychotic medication.

[18] Insight SBS television 27 July 2010 transcript available at http://news.sbs.com.au/insight/episode/index/id/272#transcript

[19] $440 million of this has been allocated to Early Psychosis Prevention and Intervention Centres and an additional $255 million to “Headspace”, where McGorry and Hickie are directors.

[20] Orygen Youth Health, EPPIC: About Us http://www.eppic.org.au/about-us (3 August 2010)

[21] McGorry P.D. ‘Is early intervention in the major psychiatric disorders justified? Yes’, BMJ 2008;337:a695 http://www.bmj.com/cgi/content/full/337/aug04_1/a695 (3 August 2010)

[22] Address to the National Press Club Canberra by Prof. Patrick McGorry July 7, 2010

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